Research Article | Volume: 2 Issue: 8, August 2012

Quantitative determination of Asenapine in both bulk and formulations using neutralization titrations

Kiran Aarelly,  Manish Kumar Thimmaraju,  Raghunandan Nerella   
Kiran Aarelly, Manish Kumar Thimmaraju, Raghunandan Nerella

Balaji Institute of Pharmaceutical Sciences Narsampet, Warangal, 506331, India.

Open Access    DOI: 10.7324/JAPS.2012.2824

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Abstract

Asenapine is used in the treatment of schizophrenia disease.Asenapine mainly control the psychotic symptoms’ mainly antagonist to various receptors like, serotonin (5-HT1A, 5-HT1B,5-HT2A,5-HT2B,),histamine, and dopamine(D1,D2,D3,D4) receptors. It is also lower affinity towards muscaranic and acetylcholine receptors. In the present study, simple titrimetric method was developed. Respective quantities of Asenapine were taken in aqueous methanol titrated against 0.1N sodium hydroxide acid and 0.1N potassium hydroxide acid using phenolphthalein as an indicators for neutralization titration. This method were found to be sensitive and inexpensive, do not require any sample processing steps and can be utilized for estimation of asenapine in bulk and formulations.


Keyword:     Asenapine titrimetrysodium hydroxide potassium hydroxide methanol.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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