Review Article | Volume: 2 Issue: 8, August 2012

Proteomics in Drug Discovery

Yeakuty Marzan Jhanker,  Mohammad Fahim Kadir,  Rajibul Islam Khan Rubaiyat Hasan   
Yeakuty Marzan Jhanker1, Mohammad Fahim Kadir1, Rajibul Islam Khan1 Rubaiyat Hasan2

1Department of Pharmacy, University of Asia pacific, Dhanmondi, Dhaka-1205, Bangladesh.

2Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia-7003, Bangladesh.

Open Access    DOI: 10.7324/JAPS.2012.2801

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Abstract

Drug discovery is a lengthy and highly expensive process that uses a variety of tools from diverse fields. To facilitate the process, several biotechnologies, including genomics, proteomics, cellular and organismic methodologies have been developed. The present review aims to provide a basic understanding of proteomics research by discussing the methods used to study large numbers of proteins and by reviewing the application of proteomics methods to identify biomarkers, to identify drug target and to conduct drug’s mode of action and toxicology studies. It is expected that this will lead to important new insights into disease mechanisms and improved drug discovery strategies to produce novel therapeutics.


Keyword:     Proteomics Drug Discovery Biomarker Target Identification Lead identification Pharmacoproteomics.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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